PREGNANCY-ASSOCIATED BREAST CANCER: THERAPEUTIC DECISIONS AND MATERNAL AND FETAL OUTCOMES

Authors

  • João Gabriel Garrote Vasconcelos
  • Bianca Oliveira Bomfim
  • Luísa Campos Castro
  • Isabella de Oliveira e Castro
  • Ana Clara Bergamini Ferreira Pinheiro Rodrigues
  • Milena Dourado Brasileiro
  • Karine Harumi de Castro Shimasaki
  • Giovanna Rocha Placido Concesso
  • Gabriella Tolentino Fleury
  • Sara Batista Vaz

DOI:

https://doi.org/10.63330/sasciencesv6n2-281

Keywords:

Breast neoplasms, Maternal and child health, Pregnancy, Pregnancy outcome, Therapeutics

Abstract

Breast cancer diagnosed during pregnancy presents therapeutic challenges involving maternal cancer treatment and the assessment of potential effects on the fetus. This narrative review aimed to analyze treatment decisions in this context and their relationship with maternal, fetal, and neonatal outcomes. Clinical guidelines and scientific publications on the diagnosis, treatment, and follow-up of patients with cancer during pregnancy and of children exposed to anticancer therapies in utero were analyzed. The studies indicated that surgery can be performed during pregnancy and that certain chemotherapy regimens may be considered from the second trimester onward. Other treatment modalities, such as endocrine therapy and HER2-targeted therapies, have restrictions during pregnancy. Maternal and neonatal outcomes were generally favorable in selected patients, although interpretation is limited by the heterogeneity of the studies and the predominance of observational data. It is concluded that treatment decisions should consider tumor stage and subtype, gestational age, associated risks, and patient preferences. Multidisciplinary care, delivery planning, and follow-up of children are essential for continuity of care.

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References

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Published

2026-11-04

How to Cite

Vasconcelos, J. G. G. ., Bomfim, B. O. ., Castro, L. C. ., de Oliveira e Castro, I. ., Rodrigues, A. C. B. F. P. ., Brasileiro, M. D. ., Shimasaki, K. H. de C. ., Concesso, G. R. P. ., Fleury, G. T. ., & Vaz, S. B. . (2026). PREGNANCY-ASSOCIATED BREAST CANCER: THERAPEUTIC DECISIONS AND MATERNAL AND FETAL OUTCOMES . South American Sciences, 6(2), e26509. https://doi.org/10.63330/sasciencesv6n2-281

Issue

Vol. 6 No. 2 (2026): South American Sciences

Section

Artigos

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