RELATIONSHIP BETWEEN PERIODONTAL DISEASE, PERIODONTITIS, AND OBESITY: A NARRATIVE LITERATURE REVIEW

Authors

  • Davi Buss Mattei
  • Luciane Manenti

DOI:

https://doi.org/10.63330/sasciencesv6n2-139

Keywords:

Microbiota, Obesity, Periodontal disease, Periodontitis, Systemic inflammation

Abstract

Obesity and periodontal disease are closely related, mainly due to shared inflammatory mechanisms that negatively affect oral health. Obesity is characterized by a state of low-grade chronic inflammation resulting from excessive adipose tissue, which releases pro-inflammatory cytokines and affects various body systems. This inflammatory state can exacerbate inflammation in the gums and periodontal tissues, leading to the destruction of tooth-supporting structures and increasing susceptibility to diseases such as periodontitis. Additionally, intestinal dysbiosis, frequently observed in obese individuals, directly influences the immune system by altering inflammatory responses and favoring the growth of pathogenic bacteria in the oral cavity. Scientific evidence indicates that obesity, particularly visceral adiposity, plays a significant role not only in the development but also in the progression of periodontal diseases, highlighting the importance of weight management in their prevention and clinical management. Understanding the bidirectional relationship between obesity and periodontal disease is crucial for clinical practice, allowing healthcare professionals to adopt more integrated, multidisciplinary, and personalized approaches. This narrative review aims to comprehensively analyze and discuss this relationship, gathering recent scientific evidence to elucidate the mechanisms linking these conditions and to provide insights for improved patient care and therapeutic strategies.

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References

PISCHON N, et al. Obesity, inflammation, and periodontal disease. J Dent Res. 2007;86(5):400–9.

CHAFFEE BW, WESTON SJ. Association between chronic periodontal disease and obesity: a systematic review and meta-analysis. J Periodontol. 2010;81(12):1708–24.

CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC). Overweight & Obesity Adult Obesity Prevalence Maps. 2016.

BAYS HE, et al. Obesity Algorithm. Centennial (CO): Obesity Medicine Association; 2020.

AZEVEDO PO, et al. Biological mechanisms involved in the intercession between obesity and periodontitis. Res Soc Dev. 2020;9(11):e52491110092.

BLÜHER M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288–98.

HOTAMISLIGIL GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860–7.

ADAMCZAK M, WIECEK A. The adipose tissue as an endocrine organ. Semin Nephrol. 2013;33:2–13.

FURUTA M, SHIMAZAKI Y, TAKEUCHI K. Periodontal health and metabolic syndrome in middle-aged adults: the Hisayama Study. J Dent Res. 2019;98(11):1221-8.

MARTINS RS, OPPERMANN RV, RÖSING CK. Obesity and periodontitis: an update on the possible links. Rev Gaúch Odontol. 2021;69:e20210043

PELLEGRINI G, SEILER TG, SAHRMANN P. Influence of overweight and obesity on the development and progression of periodontal disease: a systematic review. J Clin Periodontol. 2022;49(5):446-62.

LUNDBERG K, WEGMANN F, YUCEL-LINDBERG T. Inflammatory biomarkers in obese patients with periodontitis: a cross-sectional clinical study. Clin Oral Investig. 2021;25(7):3975-84.

HAJISHENGALLIS G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15(1):30–44.

OPPERMANN RV. Atenção integral em saúde bucal: desafios para o SUS. Porto Alegre: Editora da UFRGS; 2020.

NASCIMENTO GG, LEITE FRM, PERES KG, DEMARCO FF, CORREA MB. Obesity and periodontitis: a population-based study in southern Brazil. J Clin Periodontol. 2019;46(8):854-62.

DÍAZ-GARRIDO N, BADET C, GUILLET H, VIENNOT S. Obesity-related oxidative stress and periodontal disease: insights into molecular mechanisms. Antioxidants. 2021;10(8):1251.

DURHAM J, et al. Impact of periodontitis on oral health-related quality of life. J Dent. 2013;41:370–6.

PINHO CPS, et al. Prevalência e fatores associados à obesidade abdominal em indivíduos na faixa etária de 25 a 59 anos do Estado de Pernambuco, Brasil. Cad Saúde Pública. 2013;29:313–24.

LACKEY DE, OLEFSKY JM. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol. 2016;12(1):15–28

BEZERRA BB, SALLUM EA, SALLUM AW. Obesity and periodontal disease: why suggest such relationship? Braz J Oral Sci. 2007;6(23):1420–2.

KHADER YS, et al. The association between periodontal disease and obesity among adults in Jordan. J Clin Periodontol. 2009;36(1):18–24.

BENJAMIN W, et al. Association between chronic periodontal disease and obesity: a systematic review and meta-analysis. J Periodontol. 2010;81(12):1708–24.

BECK JD, OFFENBACHER S. Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease. J Periodontol. 2005;76(11 Suppl):2089–100.

RITCHIE CS, KINANE DF. Nutrition, inflammation and periodontal disease. Nutr. 2003;19(5):475–6.

MARTINS CC, et al. Obesity and periodontal diseases: systematic review and meta-analysis. Rev Bras Epidemiol. 2017;20(1):150–62.

PISARSKA K, et al. Obesity and periodontal disease: a review of the literature. Int J Environ Res Public Health. 2020;17(20):1–13

ALARCÓN-SÁNCHEZ MA. Influence of obesity on subgingival microbiota composition in subjects with different periodontal status: a systematic review. Rev Cient Odontol. 2024;12(1):1–10.

ZEIGLER CC, et al. Microbiota in the oral subgingival biofilm is associated with obesity in adolescence. Obesity (Silver Spring). 2019;27(11):1761–8.

CZESNIKIEWICZ-GUZIK M, GÓRSKA R, SIEDLINSKI M, GUZIK TJ. Mechanisms linking periodontal disease with obesity and metabolic dysfunction. Int J Mol Sci. 2023;24(6):5331.

MIZUTANI S, et al. Relationship between xerostomia and gingival condition in young adults. J Periodontal Res. 2015;50:74–9.

ÖSTBERG AL, et al. Oral health and obesity indicators. BMC Oral Health. 2012;12:50.

ABU-SHAWISH G, BETSY J, ANIL S. Is obesity a risk factor for periodontal disease in adults? A systematic review. Int J Environ Res Public Health. 2022;19:12684

Published

2026-08-21

How to Cite

Mattei, D. B. ., & Manenti, L. . (2026). RELATIONSHIP BETWEEN PERIODONTAL DISEASE, PERIODONTITIS, AND OBESITY: A NARRATIVE LITERATURE REVIEW. South American Sciences, 6(2), e26365. https://doi.org/10.63330/sasciencesv6n2-139