RESISTANCE OF SOIL TRANSMITTED HELMINTHS TOWARDS BENZIMIDAZOLES: A LITERATURE REVIEW

Authors

  • Eriton Ronaldo Maria
  • Orozimbo Furlan Junior
  • Alexandre Antunes Ribeiro Filho

DOI:

https://doi.org/10.63330/sasciencesv6n2-007

Keywords:

Soil helminths transmitted, Resistance of Benzimidazoles, B-tubulin

Abstract

Helminths transmitted by contact with soil, also called soil transmitted helminths, Ascaris lumbricoides; Trichuris trichiura; and hookworms, Necator americanus and Ancylostoma duodenale, are parasites that cause significant morbidity and mortality in endemic countries, contributing to a burden of more than 3 million years of disability-adjusted life (DALY). Considering the severity of the symptoms that the helminths transmitted by contact with the soil can trigger in the host, intervention with prophylaxis and therapeutic measures are expressly relevant. Treatment with benzimidazoles is the most widely used means of combating these parasites. However, the widespread use of these drugs can select strains of drug-resistant parasites. This review will report on mass administration programs, the burden caused by the disease and the resistance mechanisms of helminths against benzimidazoles in humans, focusing on the molecular mechanisms of resistance to benzimidazoles, albendazole and mebendazole, and how resistance is diagnosed.

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Published

2026-06-08

How to Cite

Maria, E. R. ., Furlan Junior, O. ., & Ribeiro Filho, A. A. . (2026). RESISTANCE OF SOIL TRANSMITTED HELMINTHS TOWARDS BENZIMIDAZOLES: A LITERATURE REVIEW. South American Sciences, 6(2), 1–7. https://doi.org/10.63330/sasciencesv6n2-007